Question: Some viruses, such as SV40, contain closed circular DNAs carrying nucleosomes. If the SV40 viral chromosome is treated with topoisomerase, and the histone is then

Some viruses, such as SV40, contain closed circular DNAs carrying nucleosomes. If the SV40 viral chromosome is treated with topoisomerase, and the histone is then removed, it is still supercoiled. If histones are removed before topoisomerase treatment, however, the DNA is relaxed. Explain.

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