Figure 4.101 shows drug concentration curves after oral administration of 0.5 mg of four digoxin products. All the tablets met current USP standards of potency, disintegration time, and dissolution rate.(a) Discuss differences and similarities in the peak concentration and the time to reach peak concentration.

(b) Give possible values for minimum effective concentration and maximum safe concentration that would make Product C or Product D the preferred drug.

(c) Give possible values for minimum effective concentration and maximum safe concentration that would make Product A the preferred drug.

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concentration 1.5 1 0.5 B COR с D 12 3 Figure 4.101 4 5 1 (hours)