Gemcitabine is a deoxycytidine analog used in treating pancreatic and ovarian cancer. The drug requires metabolic activation
Question:
Gemcitabine is a deoxycytidine analog used in treating pancreatic and ovarian cancer. The drug requires metabolic activation after uptake into cells. Speculate on the pathway for activation and the identity of the target enzyme.
Transcribed Image Text:
HO LL F OH F NH₂ I
Fantastic news! We've Found the answer you've been seeking!
Step by Step Answer:
Answer rating: 50% (4 reviews)
Gemcitabine is a prodrug that requires metabolic activation within cells to exert its cytotoxic effe...View the full answer
Answered By
Rinki Devi
Professional, Experienced, and Expert tutor who will provide speedy and to-the-point solutions.
Hi there! Are you looking for a committed, reliable, and enthusiastic tutor? Well, teaching and learning are more of a second nature to me, having been raised by parents who are both teachers. I have done plenty of studying and lots of learning on many exciting and challenging topics. All these experiences have influenced my decision to take on the teaching role in various capacities. As a tutor, I am looking forward to getting to understand your needs and helping you achieve your academic goals. I'm highly flexible and contactable. I am available to work on short notice since I only prefer to work with very small and select groups of students.
I have been teaching students for 5 years now in different subjects and it's truly been one of the most rewarding experiences of my life. I have also done one-to-one tutoring with 100+ students and helped them achieve great subject knowledge.
5.00+
2+ Reviews
10+ Question Solved
Related Book For
Biochemistry Concepts And Connections
ISBN: 9780134641621
2nd Edition
Authors: Dean Appling, Spencer Anthony-Cahill, Christopher Mathews
Question Posted:
Students also viewed these Sciences questions
-
A hypothetical three-step metabolic pathway consists of intermediates W, X, Y, and Z and enzymes A, B, and C. Deduce the order of the enzymatic steps in the pathway from the following information: 1....
-
The PI3K/AKT signaling pathway is aberrant in a wide variety of cancers. In soft-tissue sarcoma (STS) cells, AKT1 activation induces cell motility and invasiveness, which leads to aggressive...
-
In eukaryotes, the three RNA polymerases, Pol I, II, and III, each transcribes unique genes required for the synthesis of ribosomes: 25S and 18S rRNAs (Pol 1), 55 rRNA (Pol III), and mRNAs for...
-
Presented below is Trident Company's Income Statement prepared on the traditional (functional) basis: Requirement 1: Replace the two unknown amounts (?) in A. and B. as directed. To find the unknown...
-
Dora Company uses a client-server network for its accounting system. The companys database servers are kept at a central computer center. Users of the system access the companys database through...
-
Assuming that in Problem 8.70 a right-handed thread is used on both rods A and B, determine the magnitude of the couple that must be applied to the sleeve in order to rotate it.
-
Conventional accounting provides information about a cluster of financial circumstances that are of concern to all stakeholders.What are these circumstances?
-
Moon Co., Inc., made several purchases of long-term assets in 2010. The details of each purchase are presented here. New Office Equipment 1. List price: $60,000; terms: 2/10 n/30; paid within...
-
14. A small potato was put in the oven then taken out to cool. The temperature in degrees of the potato at time t (in minutes) is represented by the function T(t). Rephrase each of the equations...
-
The paper cited in References by Franzolin et al. (2013) presents evidence that dNTP pool sizes are controlled not only at the level of dNTP synthesis (RNR), but also at the level of dNTP breakdown,...
-
Oxidation of DNA bases is mutagenic. An oxidized form of guanine, 8-oxoguanine, can base-pair with adenine, leading to errors in DNA replication. A gene called mutT acts to minimize the tendency of...
-
Can you calculate the local speed of sound if you know ALT only? Is it true that the speed of sound definitely increases if both the air pressure and density are increasing?
-
Current Attempt in Progress On May 1, 2022. Sunland Corp. issued $850,000. 9%, 5-year bonds at face value. The bonds were dated May 1, 2022, and pay interest annually on May 1. Financial statements...
-
1.Define and analyze the five project management processes in terms of applicability to HMIS implementation needs. 2. Locate and evaluate at least two project management tools and compare their...
-
Converse Limited is a manufacturing company with a 31 December year-end. The company owns a variety of assets, and they use the following accounting policies to account for their assets: Land and...
-
Which number line shows the solution of the inequality 2n3 5n-6? F -6-5-4-3-2-1 0 1 2 3 4 5 6 G -6-5-4-3-2-1 0 1 2 3 4 5 6 H HI ++ -6-5-4-3-2-1 0 1 2 3 4 5 6 J ++ -6-5-4-3-2-1 0 1 2 3 4 5 6 Show your...
-
Autumn wants $7,000 saved in 3 years to make a down payment on a house. How much money should she invest now at 4.85% compounded monthly in order to meet her goal?
-
In the Journal of the International Association for Shell and Spatial Structures (April 2004), Japanese environmental researchers studied the performance of truss-and-frame structures subjected to...
-
Drainee purchases direct materials each month. Its payment history shows that 65% is paid in the month of purchase with the remaining balance paid the month after purchase. Prepare a cash payment...
-
What enzymes are known to be involved in Alzheimers disease?
-
What is the most significant difference between prion diseases and other diseases caused by amyloid-type plaques, such as Alzheimers disease?
-
How are researches working with extended families in Medellin, Colombia to look for methods of fighting Alzheimers disease?
-
Your health facility, the Lakeland Medical Clinic was opened to serve area residents. The first two months of operation saw strong patient volume after which the numbers dropped off dramatically....
-
Critically analyse the following statement: 'The Human Rights Act 1998 gives judges too much power to undermine Parliament' To what extent do you agree? Refer to both parliamentary sovereignty and...
-
Leadership is an integral element in any job, regardless of the work title. However, it is important to recognize that leadership is not just one single skill; instead, success in leadership depends...
Managing And Leading People Through Organizational Change 1st Edition - ISBN: 074947419X - Free Book
Study smarter with the SolutionInn App