With reference to the REPOSE trial (2017) of Section 15.6 which of the following statements, if any,
Question:
With reference to the REPOSE trial (2017) of Section 15.6 which of the following statements, if any, are true A. The subjects were blind to treatment.
B. The subjects were randomised individually to MDIs or pumps.
C. All subjects got pumps in the end.
D. The trial showed a clear benefit of pumps compared with MDIs.
E. The cluster size was about five.
Section 15.6
Transcribed Image Text:
Population Assessment 15.6 Design Options Parallel Designs In a parallel design, one group receives the test treatment, and one group the control as represented in Figure 15.1. Eligible and willing subjects Randomisation Control Figure 15.1 Stages of a parallel two group randomised controlled trial. Example from the Literature - Parallel Group Trial - Reduced Nicotine Cigarettes Allen et al. (2017) plan to randomly allocate 200 adult smokers with a current or lifetime unipolar mood and/or anxiety disorder to receive either usual nicotine (UN) cigarettes or reduced nicotine (RN) cigarettes with the nicotine reduced in five steps over 18 weeks. The subjects will smoke regular nicotine cigarettes for two weeks prior to randomisation. The primary outcome will be blood cotinine, and secondary outcomes include anxiety and depression measures. Participants and study staff will be blind to the experimental cigarette allocation from the randomisation visit to the last visit. The RN cigarettes will be identical in appearance to the UN Test Assessment
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Medical Statistics A Textbook For The Health Sciences
ISBN: 9781119423645
5th Edition
Authors: Stephen J. Walters, Michael J. Campbell, David Machin
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