Rearrange the order of the following statements to give a flow diagram showing the evolution of resistance to the antibiotic streptomycin by the bacterium Escherichia coli.

1. Most of the population of E. coli is resistant to streptomycin.

2. A mutation in a DNA triplet of a plasmid, changing TTT to TTG, gives an E. coli bacterium resistance to streptomycin.

3. The resistant bacterium divides and passes copies of the R plasmid (plasmid with gene for resistance to antibiotic) to its off spring.

4. Sensitive bacteria die in the presence of streptomycin as a selective agent.

5. The frequency of the mutated gene in the population increases.

6. The resistant bacterium has a selective advantage and survives.