2. Refer to the data in Table 2.3, also available on the web in WinBUGS format at http://www.biostat.umn.edu/~brad/data.html. These pharmacokinetic (PK) data of Wakefield et al. (1994) were initially presented in Example 2.13, and analyzed there using an approximate linear hierarchical model. Recall these are the plasma concentrations Yij of the drug cadralazine at up to T = 8 different time lags xij following the administration of a single dose of 30 mg in N = 10 cardiac failure patients. Here, i = 1,..., 10 indexes the patient, while j = 1,...,ni indexes the observations, where 5 ≤ ni ≤ 8. Wakefield et al. suggest a “one-compartment”

nonlinear pharmacokinetic model wherein the mean plasma concentration ηij (xij ) at time xij is given by