Estimate the effective pore diffusivity, , of a monoclonal antibody in a water-saturated porous particle with porosity  = 0.60 at20°C. The pore radius is  = 20 nm and the tortuosity factor is = 2.0.The diffusivity of the protein in water can be estimated from the Tyn &

Gusek equation. The radius of the protein can be estimated from this diffusivity value using the Stokes–Einstein equation. The monoclonal antibody is a globular protein with molecular mass 150,000.

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