In 1913, biochemists Leonor Michaelis and Maude Menten proposed the rational function model (see figure) for the

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In 1913, biochemists Leonor Michaelis and Maude Menten proposed the rational function model (see figure)

v (s) = Vmax S KM + s

for the velocity of the enzymatic reaction v, where s is the substrate concentration. The constants Vmax and KM are determined from experimental data. 

Vmax Vmax 2 V KM Michaelis-Menten function v(s) = Vmax S KM + S S (A) Show that lim v(s) = Vmax S-00 Vmax (B) Show that v(KM) 2 (C) Table 10 lists data for the substrate

Table 10 S 5.2 10.4 20.8 41.6 83.3 167 333 V 0.866 1.466 2.114 2.666 3.236 3.636 3.636 estimate the value of

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