Dinitrophenol (DNP) is a small molecule that renders membranes permeable to protons. In the 1940s, small amounts

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Dinitrophenol (DNP) is a small molecule that renders membranes permeable to protons. In the 1940s, small amounts of this highly toxic compound were given to patients to induce weight loss. DNP was effective in melting away the pounds, especially promoting the loss of fat reserves. Can you explain how it might cause such loss? As an unpleasant side reaction, however, patients had an elevated temperature and sweated profusely during the treatment. Provide an explanation for these symptoms.

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Essential Cell Biology

ISBN: 9780393680362

5th Edition

Authors: Bruce Alberts, Karen Hopkin, Alexander Johnson, David Morgan, Martin Raff, Keith Roberts, Peter Walter

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