Question: 8.42 An herb for depression? Does the herb Saint-John'swort relieve major depression? Here are some excerpts from the report of a study of this issue.'

8.42 An herb for depression? Does the herb Saint-John'swort relieve major depression? Here are some excerpts from the report of a study of this issue.'® The study concluded that the herb is no more effective than a placebo.

(a) "Design: Randomized, double-blind, placebo-controlled clinical trial "A clinical trial is a medical experiment using actual patients as subjects. Explain the meaning of each of the other terms in this description.

(b) "Participants .. .were randomly assigned to receive either Saint-John's-wort extract (n = 98) or placebo (n = 102)—

The primary outcome measure was the rate of change in the Hamilton Rating Scale for Depression over the treatment pe riod." Based On this information, use a diagram to outline the design of this clinical trial.

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