Intestinal bacteria convert choline to trimethylamine, and the liver converts this gas to trimethylamine N-oxide (TMAO). TMAO

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Intestinal bacteria convert choline to trimethylamine, and the liver converts this gas to trimethylamine N-oxide (TMAO). TMAO promotes atherosclerosis, possibly by stimulating macrophages to take up LDL.

(a) Could this chemistry explain why eating large amounts of eggs (which are rich in phosphatidylcholine) is a risk factor for cardiovascular disease?

(b) Some research suggests that ingesting supplemental phosphatidylcholine can slow the aging process. Is this consistent with your answer to Part (a)?

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Fundamentals Of Biochemistry Life At The Molecular Level

ISBN: 9781118918401

5th Edition

Authors: Donald Voet, Judith G Voet, Charlotte W Pratt

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