Salsolinol (Fig. P19.61) is formed in the brain when acetaldehyde reacts with dopamine. Because acetaldehyde is a
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Salsolinol (Fig. P19.61) is formed in the brain when acetaldehyde reacts with dopamine. Because acetaldehyde is a biological oxidation product of ethanol (Sec. 10.8), it has been suggested that salsolinol might be used as a biological marker for alcohol consumption. Draw a curved-arrow mechanism for the formation of salsolinol from acetaldehyde and dopamine. Assume acids and bases are present as needed.
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The first step is the formation of an imine by the standard mechanism The imine carbonnitrogen dou...View the full answer
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