Using abbreviated structures like the ones in Eq. 25.9a, give a curved-arrow mechanism for the reduction of

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Using abbreviated structures like the ones in Eq. 25.9a, give a curved-arrow mechanism for the reduction of mevaldehyde shown in Eq. 25.9b.protein (CH)4-N-H- protonated lysine residue of the enzyme hydride transfer H mevaldehyde H H protein (CH),

R :0: I H HHO H :H NH NH J L fl + + H R' R mevalonate NADPH NADP+ mevaldehyde + + HO (25.9b)

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Organic Chemistry

ISBN: 9781936221349

6th Edition

Authors: Marc Loudon, Jim Parise

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