In what ways does chromosomal DNA replication in eukaryotes differ from DNA replication in prokaryotes?
(1) DNA replication usually occurs continuously in rapidly growing prokaryotic cells but is restricted to the S phase of the cell cycle in eukaryotes. 

(2) Most eukaryotic chromosomes contain multiple origins of replication, whereas most prokaryotic chromosomes contain a single origin of replication. 

(3) Prokaryotes utilize two catalytic complexes that contain the same DNA polymerase to replicate the leading and lagging strands, whereas eukaryotes utilize two or three distinct DNA polymerases for leading and lagging strand synthesis.
(4) Replication of eukaryotic chromosomes requires the partial disassembly and reassembly of nucleosomes as replisomes move along parental DNA molecules. In prokaryotes, replication probably involves a similar partial disassembly/reassembly of nucleosome- like structures. 

(5) Most prokaryotic chromosomes are circular and thus have no ends. Most eukaryotic chromosomes are linear and have unique termini called telomeres that are added to replicating DNA molecules by a unique, RNA-containing enzyme called telomerase.