Inherited cancers like retinoblastoma show a dominant pattern of inheritance. However, the underlying genetic defect is a
Question:
Inherited cancers like retinoblastoma show a dominant pattern of inheritance. However, the underlying genetic defect is a recessive loss-of-function mutation—often the result of a deletion. How can the dominant pattern of inheritance be reconciled with the recessive nature of the mutation?
Fantastic news! We've Found the answer you've been seeking!
Step by Step Answer:
Answer rating: 76% (13 reviews)
At the cellular level lossoffunction mutations in the RB ...View the full answer
Answered By
Wahome Michael
I am a CPA finalist and a graduate in Bachelor of commerce. I am a full time writer with 4 years experience in academic writing (essays, Thesis, dissertation and research). I am also a full time writer which assures you of my quality, deep knowledge of your task requirement and timeliness. Assign me your task and you shall have the best.
Thanks in advance
4.90+
63+ Reviews
132+ Question Solved
Related Book For
Principles of Genetics
ISBN: 978-1119142287
7th edition
Authors: D. Peter Snustad, Michael J. Simmons
Question Posted:
Students also viewed these Life Sciences questions
-
What is the underlying genetic defect that causes xeroderma pigmentosum? How can the symptoms of this disease be explained by the genetic defect?
-
Describe how a biparental pattern of extranuclear inheritance would resemble a Mendelian pattern of inheritance for a particular gene. How would they differ?
-
A genetic predisposition to developing cancer is usually inherited as a dominant trait. At the level of cellular function, are the alleles involved actually dominant? Explain why some individuals who...
-
Discuss Planning & Preparation in relation to: Preparing work documents and performing document review Preparing an audit plan
-
State the formula for the following: (a) Converting r to a t statistic (b) Converting r to a 2 statistic
-
Data for Granger Inc. are presented in P12-9A. Further analysis reveals that accounts payable pertain to merchandise creditors. In P12-9A, Condensed financial data of Granger Inc. follow. Additional...
-
Discuss the theoretical bases for the four HR administrative approaches introduced in this chapter. Are such theories useful to HR professionals in their efforts to improve transactional performance?...
-
Wallowa Company is considering a long-term investment project called ZIP. ZIP will require an investment of $120,000. It will have a useful life of 4 years and no salvage value . Annual cash inflows...
-
1. What do the totals at the end of the journal entry report mean? 2. What was the net income of Binh's Bins for the month of June? 3. How much did the company owe to the creditors (recorded as...
-
A large tank is filled with methane gas at a concentration of 0.650 kg/m3. The valve of a 1.50-m pipe connecting the tank to the atmosphere is inadvertently left open for twelve hours. During this...
-
The following pedigree shows the inheritance of familial ovarian cancer caused by a mutation in the BRCA1gene. Should II-1 be tested for the presence of the predispos-ing mutation? Discuss the...
-
Approximately 5 percent of the individuals who inherit an inactivated RBgene do not develop retinoblastoma. Use this statistic to estimate the number of cell divisions that form the retinal tissues...
-
Determine the domain and the range of the given functions. F(x) = 3 |x|
-
Think about stereotypes that you see on television or negative portrayals of gender, and different races on television. How do these portrayals influence how we think about others and even how we...
-
1. Where do you get your news? List the primary sources that you turn to for facts, culture, headlines etc. Why does this list represent solid, reputable news sources to you? 2. The video Fear and...
-
Homeland Security Threat Analysis Free societies are at risk for terrorist acts for several reasons: a) loose control of public information; b) weapons, communications equipment, and explosives are...
-
Modern language teaching methods highly encourage the use of multimodal response approaches to help learners read/write about literary texts in fun ways. Pretend you have to teach the following poem...
-
Polls and their results clearly impact the way in which some people think and feel about issues. Have the results of a poll or survey ever consciously impacted your opinions? Describe some of the...
-
A 12-ft-long, 3-in.-OD iron pipe = 0.7, passes horizontally through a 12 14 9 ft room whose walls are maintained at 70F and have an emissivity of 0.8. The pipe surface is at a temperature of 205F....
-
What kind of financial pressures can an LBO cause?
-
A researcher hypothesizes that in mice gene A is actively transcribed in liver cells, whereas gene B is actively transcribed in brain cells. Describe procedures that would allow the researcher to...
-
Epigenetic states are transmitted clonally through cell division. What kinds of observations indicate that these states can be reversed or reset?
-
Suppose that female mice homozygous for the a allele of the Igf2 gene are crossed to male mice homozygous for the b allele of this gene. Which of these two alleles will be expressed in the F 1...
-
Write an equation for the polynomial graphed below 5+ 4 + -5-4-3-2 y = 3. 2- 1 + + 2 3 4 5 -2 345 -5+
-
How can ethical leadership principles be leveraged to navigate the complexities of organizational dynamics and promote a culture of integrity, accountability, and social responsibility ?
-
Consider the 12-QAM constellation shown in Figure 2 and the baseband pulse, g(t) depicted in Figure 3. The 12 passband transmit waveforms are represented as Sm1(t) = Amig(t) cos (2fet) - Amag(t) sin...
Study smarter with the SolutionInn App