The RNA from the Drosophila Sex-lethal (Sxl) gene is alternately spliced. In males, the sequence of the

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The RNA from the Drosophila Sex-lethal (Sxl) gene is alternately spliced. In males, the sequence of the mRNA derived from the primary transcript contains all eight exons of the Sxl gene. In females, the mRNA contains only seven of the exons because during splicing exon 3 is removed from the primary transcript along with its flanking introns. The coding region in the female’s mRNA is therefore shorter than it is in the male’s mRNA. However, the protein encoded by the female’s mRNA is longer than the one encoded by the male’s mRNA. How might you explain this paradox?

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Principles of Genetics

ISBN: 978-1119142287

7th edition

Authors: D. Peter Snustad, Michael J. Simmons

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