Question: Cystic Fibrosis is a severe, usually fatal, disease in humans caused by homozygosity for a recessive allele. The frequency of the disease is about 0.0006.

Cystic Fibrosis is a severe, usually fatal, disease in humans caused by homozygosity for a recessive allele. The frequency of the disease is about 0.0006.

1. What is the frequency of thecfallele?

2. What is the expected frequency of individuals who are heterozygous for this allele (carriers)?

3. What is the probability that two individuals who mate are both carriers assuming mating is random?

4. What assumptions did you have to make to get your answer?

5. Why has this disease not been eliminated by natural selection?

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To address these questions we can apply the HardyWeinberg principle which provides a foundation for understanding genetic allele frequencies and their ... View full answer

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