$01$:$00$:$07$

Time Remaining

Briefly explain the processes that lead to the development of central and peripheral tolerance.

Word Bank:

Active

Aid

Anergic

CD$4+$ T cells

CD$8+$ T cells

Central

Leukocytes

Lymphocytes

Macrophages

NK cells

Non$-$self antigens

Peripheral

Regulatory T cells

Self antigens

tolerance is established by the deletion of in primary lymphoid organs if they possess

receptors that can react with self antigens, or by the emergence of hat can inhibit the actions of other self$-$reactive cells. tolerance involves deleting, rendering or actively suppressing $($via induction of $T_{\text{r}\text{e}\text{g}}$ cells$)$ escaped lymphocytes that possess receptors that are self$-$reactive. This process occurs primarily in secondary lymphoid organs.