$100$

The end$-$replication problem $($telomere problem$)$ exists in eukaryotic chromosomes and is characterized by the chromosomes shortening with each round of DNA replication.

$100$

$100$

Select the statements that best explain why the end$-$replication problem exists in eukaryotic chromosomes.

DNA polymerase synthesizes DNA from the $5^{\text{'}}$ end to the $3^{\text{'}}$ end.

DNA ligase links the $5^{\text{'}}OH$ group of one fragment to the $3^{\text{'}}$ phosphate group of an adjacent fragment.

DNA polymerase requires a primer for DNA synthesis.

The lagging strand is synthesized from the $3^{\text{'}}$ end to the $5^{\text{'}}$ end.

The RNA primer is removed in a $3^{\text{'}}$ to $5^{\text{'}}$ direction.