1. Explain the dose-rate effect resulting from the following processes: (a) Repair of sublethal damage, (b) Redistribution in the cycle, and (c) Cell proliferation [incorporate proper graphical representation in your answer]. [5]. 2. Differentiate between Fractionation, Hyper-fractionation, and Hypo-fractionation. What should be the ideal fractionation curve? [3+2] 3. What is the oxygen enhancement ratio ? How does it play a role in further decreasing the survival fraction, even by using only a low dose of radiation? Explain with suitable graphs. (1+2+2] 4. How does the process of reoxygenation influence the tumor response to radiation? Explain linear energy transfer with an appropriate equation. [2+3] 5. What do you mean by spurs and blobs? How can one measure the effect of ionizing radiation that leads to induction of DNA strand breaks? Explain the mechanism of any radio-immunotherapy agent in treating cancer. (1+2+2]