1. Please could you explain how lymphocytes (especially B) can maintain

2. receptors on their surfaces? Is this genetically related? If so, when the

3. lymphocytes are first exposed to the antigens, how could the antigen

4. receptor be synthesized?

5. Is there a mutation within the nuclei of these lymphocytes when they

6. learn to make the receptors? If there is, can you explain how this occurs?

7. I understand how nuclear factor-B (NFB) works in the inflammatory

8. response but what is the mechanism by which it causes cancer?

9. What are the diseases associated with hypocomplementaemia and which

10. complement deficiency in particular?

11. What is meant by 'B lymphocytes are sensitive to clonal deletion'?

12. What are the immunological implications of 'bare lymphocyte

13. syndrome'/MHC deficiency?

14. Please explain oligoclonal and monoclonal.

15. I was wondering if there is any study regarding cell culture techniques of

16. CD4 helper cells (stem cell culturing) and, if so, is it of any benefit to

17. HIV-infected patients

18. How do you define autoimmune disease?

1. Why is dexamethasone not routinely used instead of prednisolone,

19. which is almost universally used routinely in autoimmune diseases, or

20. other indications for steroids? Is it because dexamethasone lacks the

21. mineralocorticoid activity seen with prednisolone and therefore does

22. not cause salt/water retention and hypertension?

2. Can high doses of dexamethasone be used in acute relapses of

23. multiple sclerosis (MS) in place of pulse methylprednisolone? If so,

24. what is the recommended dosage?

25. What is meant by 'pus cell' and is this term synonymous with

26. neutrophils?