Question: 15. SAR Consideration 3: -lactamase Stability Large, bulky R groups confer stability to enzymatic degradation o balance: if group is too large, drug will lose

15. SAR Consideration 3: -lactamase Stability Large, bulky "R" groups confer stability to enzymatic degradation o balance: if group is too large, drug will lose ability to bind PBPs o may still be acid labile (if SAR 1 criteria not met)

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