2. Answer ALL parts a)-e). A multicomponent reaction process was used for the preparation of novel antiplasmodial and antitrypanosomal 4-aminoquinoline-containing a- acylamino amides such as compound 9. NH HN OH OH a) Which are the four starting materials and what are the reaction conditions used for this multicomponent reaction? b) What is the name of the multicomponent reaction used in this sequence? c) Outline the advantage of using a multicomponent reaction instead of a multistep synthesis in drug discovery. d) Provide a curly arrow mechanism for the multicomponent reaction that leads to compound 9. e) What are the structural characteristics that make compound 9 not drug-like and briefly describe how would you modify the structure to improve the drug- likeness. 3 3 2. Answer ALL parts a)-e). A multicomponent reaction process was used for the preparation of novel antiplasmodial and antitrypanosomal 4-aminoquinoline-containing a- acylamino amides such as compound 9. NH HN OH OH a) Which are the four starting materials and what are the reaction conditions used for this multicomponent reaction? b) What is the name of the multicomponent reaction used in this sequence? c) Outline the advantage of using a multicomponent reaction instead of a multistep synthesis in drug discovery. d) Provide a curly arrow mechanism for the multicomponent reaction that leads to compound 9. e) What are the structural characteristics that make compound 9 not drug-like and briefly describe how would you modify the structure to improve the drug- likeness. 3 3