3. Most proteins are covalently modified in the ER. [Pages 507-509] a) Figure 15-23 illustrates the...
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3. Most proteins are covalently modified in the ER. [Pages 507-509] a) Figure 15-23 illustrates the glycosylation of a protein specific asparagine(ASN) as the growing peptide chain enters the ER lumen. How might this co-translational process assist in recognizing which ASN to glycosylate? b) Glycosylation involves the attachment of a pre-made oligonucleotides to a protein making it into a glycoprotein. From an energy efficiency and quality control perspective, what is the advantage of attaching a preassembled oligonucleotide instead of building it on the protein block by block (by the sequential addition of monosaccharides)? Figure 15-23 Many proteins are glycosylated on asparagines in the ER. When an appropriate asparagine enters the ER lumen, it is glycosylated by addition of a branched oligosaccharide side chain Each oligosaccharide chain is transferred as an intact unit to the asparagine from a lipid called dolichol, catalyzed by the enzyme oligosaccharyl transferase. Asparagines that are glycosylated are always present in the tripeptide sequences asparagine-X-serine or asparagine-X-threonine, where X can be almost any amino acid. KEY: -glucose mannose N-acetylglucosamine dalichol lipid-linked oligosaccharide Asn NH₂ growing polypeptide chain oligosaccharyl transferase dolichol 11 Asn 0 NH₂ CYTOSOL ER LUMEN 3. Most proteins are covalently modified in the ER. [Pages 507-509] a) Figure 15-23 illustrates the glycosylation of a protein specific asparagine(ASN) as the growing peptide chain enters the ER lumen. How might this co-translational process assist in recognizing which ASN to glycosylate? b) Glycosylation involves the attachment of a pre-made oligonucleotides to a protein making it into a glycoprotein. From an energy efficiency and quality control perspective, what is the advantage of attaching a preassembled oligonucleotide instead of building it on the protein block by block (by the sequential addition of monosaccharides)? Figure 15-23 Many proteins are glycosylated on asparagines in the ER. When an appropriate asparagine enters the ER lumen, it is glycosylated by addition of a branched oligosaccharide side chain Each oligosaccharide chain is transferred as an intact unit to the asparagine from a lipid called dolichol, catalyzed by the enzyme oligosaccharyl transferase. Asparagines that are glycosylated are always present in the tripeptide sequences asparagine-X-serine or asparagine-X-threonine, where X can be almost any amino acid. KEY: -glucose mannose N-acetylglucosamine dalichol lipid-linked oligosaccharide Asn NH₂ growing polypeptide chain oligosaccharyl transferase dolichol 11 Asn 0 NH₂ CYTOSOL ER LUMEN
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Related Book For
Molecular Cell Biology
ISBN: 978-1429234139
7th edition
Authors: Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, Anthony Bretscher, Hidde Ploegh, Angelika Amon, Matthew P. Scott
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