Question: 3. Robison annulation involves a Michael addition followed by aldol condensation. The reaction is named after the English chemist, Sir Robert Robinson who won the

3. Robison annulation involves a Michael addition followed by aldol condensation.

3. Robison annulation involves a Michael addition followed by aldol condensation. The reaction is named after the English chemist, Sir Robert Robinson who won the Nobel Prize in Chemistry in 1947. For the following Robinson annulation reaction, provide the Michael addition product E and the final cyclized product F. Propose step by step mechanism for both transformations. Michael Addition -OH, CH3OH CH3 & Intramolecular aldol condensation E F O (10 marks)

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