Question: a) A spherical pill, 6.0 mm in diameter, dissolves in water flowing at 0.2 m/s. Calculate the mass transfer coefficient of the drug in the

a) A spherical pill, 6.0 mm in diameter, dissolves in water flowing at 0.2 m/s. Calculate the mass transfer coefficient of the drug in the water at 25C. The diffusivity of the drug in the water at 37C as 5.54 103 cm2/s.

b) From in vitro experiments, we know that the dissolution of this pill in the stomach is accurately described with its mass transfer coefficient in the stomach. Starting from an unsteady mass balance on the solute, show how we can estimate the average flow in the stomach by measuring the dissolution rate of the pill in the stomach.

Assume that the flow is due to forced convection, the pill diameter remains constant, and flow in and out of the stomach is negligible.

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