a.) b.) c.) d.) e.) f.)

A concerted binding model is a type of cooperative binding where a macromolecule has two structural forms in equilibrium: RT. For a concerted binding model the binding polynomial is qb=[R](1+kR[L])p+[T](1+kT[L])p. In the absence of ligand, T is more abundant than R so that K=[R][T]>1. The constants kR and kT are ligand binding constants for R and T, respectively and it is assumed R binds the ligand L more strongly than T so that c=kRkT