a) Compounds 1-3 are three of the most potent fragments from a recent screening study. For each compound, state the number of hydrogen bond donors and hydrogen bond acceptors. (3 marks)

b) Based on your donor/acceptor counts, briefly comment on the reliability of rules such as the “Rule of Three”. (1 mark)

c) What molecular property is LogP a measure of? (1 mark)

d) Compounds 1 and 3 both bind to the same pocket of the same target protein. Compare the features of the two structures, and use this to explain the term bioisosteres? (3 marks)

Transcribed Image Text:

NH2 1 3 NH2 1 3