Question: A flat tissue engineered skin (thickness 2.9 mm) is attached to the bottom of a dish and cultured with cell media atop it (which has
A flat tissue engineered skin (thickness 2.9 mm) is attached to the bottom of a dish and cultured with cell media atop it (which has an oxygen concentration of 0.15 mol/m 3 ). The diffusivity of oxygen in the skin is 3.0 E-9 m 2 /s, and according to experiments that you’ve performed, you want to make sure that the concentration of oxygen in the device doesn’t fall below 0.060 mol/m 3 . (Below that concentration harms the cells.)
The rate of oxygen consumption is -4.3 E-17 mol/[cell◦s]. What is the maximum cellularity (in cells/mL, three significant digits) that this tissue engineered skin can support?
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