A patient develops a blood infection with a capsule producing a strain of E$.$ coll. Phagocytosis by macrophage will be essential to destroy the bacteria and resolve the infection. Which of the following will be directly required to allow opsonization of the encapsulated E coliA. adsorption to host cell receptorsB. release of TNF alpha, IL$-1.$ IL$-6,$ and IL$-8$C$.$ toll$-$like receptor $($TLR$)$ binding of PAMPsD. binding of C$5$a to the C$5$a receptor $($C$5$aR$)$E$.$ release of alpha interferonF. none of the above apply