Question: A simple hidden Markov model. A two-state hidden Markov model (HMM) describing DNA sequence with a heterogeneous base composition is shown in the following figure:

A simple hidden Markov model. A two-state hidden Markov model (HMM)

A simple hidden Markov model. A two-state hidden Markov model (HMM) describing DNA sequence with a heterogeneous base composition is shown in the following figure: (a) State 1 generates AT-rich sequence, and state 2 generates CG-rich sequence. State transitions and their associated probabilities are indicated by arrows, and symbol emission probabilities for A,C,G and T for each state are indicated below the states. The initial probabilities of state 1 and 2 are 0.55 and 0.45 respectively. Evaluate the probability of an observed sequence "ATCG" in a human DNA-profile using Forward algorithm

Step by Step Solution

There are 3 Steps involved in it

1 Expert Approved Answer

Step: 1 Unlock blur-text-image

Question Has Been Solved by an Expert!

Get step-by-step solutions from verified subject matter experts

Step: 2 Unlock

Step: 3 Unlock

Students Have Also Explored These Related Databases Questions!

1. A simple hidden Markov model. A two-state hidden Markov model (HMM) describing DNA sequence with a heterogeneous base composition is shown in the following M figure: (a) State 1 generates AT-rich...

Construct a simple MAC code, and apply it to the driven lid cavity problem described in Chapter 10.As a consideration staff part, I encourage him to hold patient to the extensive variety of different...

Python and most Python libraries are free to download or use, though many users use Python through a paid service. Paid services help IT organizations manage the risks associated with the use of...

BE562: Problem Set 3 Fall 2016 Due 10/21/2016 8PM 1. Hidden Markov Models and Protein Structure (20 pts) One biological application of hidden Markov models is to determine the secondary structure...

Developments in Technology Light is incident from air on the end face of a multimode optical fibre at angle of incidence as shown below. n n 1 2 The refractive indices of the core and cladding are...

A creative engineer suggests structuring the TLB so that not all the bits of the presented address need match to result in a hit. Suggest how this might be achieved, and what might be the costs and...

io (a) Give the general formula for estimating transition probabilities from training data. Provide the full transition matrix A for this HMM based on the training data shown. [6 marks] (b) Give the...

Microkernel operating systems aim to address perceived modularity and reliability issues in traditional "monolithic" operating systems. (i) Describe the typical architecture of a microkernel...

The company currently sells 12 products through the efforts of three sales representatives to 10 restaurants. The company, like all small businesses, is always interested in finding ways to increase...

QUESTION 8 The presence of earth in case of overhead lines increases the inductance True False

The common thread in duress, undue influence and unconscionable conduct actions is the imbalance in power and position between the plaintiff and the defendant. Explain using cases to illustrate.

P-1) (100 Pts.) A chemical manufacturing company (CMC) has a contract for the procurement of the neccssaly chemicals from four suppliers. The chemicals purchased from Supplier A are priced at $20...

Locus of control: the extent to which employees feel they have sufficient control of their environment in order to benefit from performance-related pay;

Individualismcollectivism: the extent to which rewards are distributed on the basis of individual performance;

Ascriptionachievement status: the extent to which it is appropriate to reward ascribed status or achievement in the job;