A SPECT study uses Tc-99m (isotope half-life of 6.0058 hours, corresponding decay rate = 0.1154/hour). A

A SPECT study uses Tc-99m (isotope half-life of 6.0058 hours, corresponding decay rate λ = 0.1154/hour).

A patient is scanned twice for a follow-up study. The scans take 30 mins each and are 24 hours apart. The patient is administered the same activity in both scans. In the second scan, there will be residual activity from the first scan that you need to take into account. Assuming there is no biological variation nor washout (i.e. radiotracer distribution remains constant over time), compute the following ratios (second/first) for: mean detected counts and Coefficient of Variation (CV) in the detected counts. Propose a method to correct the second scan for the residual activity of the first.

Give a formula for the mean and standard deviation of the corrected counts.

Answer rating: 100% (QA)

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