A transition state inhibitor is astoundingly strong binding because it forms a covalent bond within the enzyme catalytic site. However, transition state inhibitors are "one use" since if the enzyme is degraded the inhibitor is lost with the enzyme. True False While studying the nicotinic cholinergic receptor ion channel you are trying to target the binding site at the (a) subunit, you determine that this particular channel has mutations in its gamma (g) subunit but not the delta (d) subunit. Will this have an effect on ligand binding? Yes, one of the binding sites may be deformed due to the mutations in gamma No, only alpha subunits are binding sites for this ion channel. Yes, because the gamma subunit is the binding site. No, only the delta subunit forms the binding site with the alpha subunit