Question: Although the complement cascade can be initiated by antibodies bound to the surface of a pathogen, complement activation is generally considered to be an innate

Although the complement cascade can be initiated by antibodies bound to the surface of a pathogen, complement activation is generally considered to be an innate immune response. This is because:

When the complement cascade leads to the formation of a membrane

-

attack complex, the pathogen is killed.

The C

3

convertase is only produced when complement activation is initiated by antibody binding to a pathogen.

Several of the soluble products generated by complement activation promote the inflammatory response.

Two of the three pathways for complement activation are initiated by constitutively produced recognition molecules that directly interact with microbial surfaces.

Complement proteins bound to the pathogen promote uptake and destruction by phagocytic cells.

Although the complement cascade can be initiated

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