An analyst was asked to verify the w/w % of phenobarbital in Luminal, an anti- seizure...
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An analyst was asked to verify the w/w % of phenobarbital in Luminal, an anti- seizure medication. A Luminal tablet weighing 1.1799 g was digested in 150 mL 1.0 M HCI, filtered into a 250.00 mL volumetric flask and made to the mark with reagent water. This solution was further diluted by a dilution factor of 100. 5.00 mL aliquots of the diluted solution were transferred into 50.0 mL volumetric flasks and made basic with KOH. The following volumes of a 40 ug/mL standard solution of phenobarbital were then introduced into each flask and the mixture was diluted to the mark with reagent water. The fluorescence of each solution was measured in five separate trials using spectrofluorimetry. The following data was recorded. Fluorescence Emission (Counts) Phenobarbital Std. (mL added) Trial 1 Trial 2 Trial 3 Trial 4 Trial 5 0.00 3.26 3.33 3.25 3.22 3.31 0.50 4.80 4.81 4.89 4.77 4.69 1.00 6.41 6.50 6.48 6.38 6.35 1.50 8.02 8.01 7.89 7.93 8.02 2.00 9.56 9.44 9.49 10.03 9.55 3.00 12.84 12.82 12.88 12.86 12.79 4.00 16.02 16.01 16.07 16.06 16.06 5.00 19.44 19.45 19.39 19.47 19.44 6.00 22.81 22.87 22.91 22.78 22.82 1. Evaluate the calibration data and use statistics to eliminate any outliers and/or leverage points. Plot the final calibration data and determine R2 and the equation of the line of best fit. (4 marks) 2. Report the concentration of phenobarbital in the Luminal tablet in w/w %. (6 marks) An analyst was asked to verify the w/w % of phenobarbital in Luminal, an anti- seizure medication. A Luminal tablet weighing 1.1799 g was digested in 150 mL 1.0 M HCI, filtered into a 250.00 mL volumetric flask and made to the mark with reagent water. This solution was further diluted by a dilution factor of 100. 5.00 mL aliquots of the diluted solution were transferred into 50.0 mL volumetric flasks and made basic with KOH. The following volumes of a 40 ug/mL standard solution of phenobarbital were then introduced into each flask and the mixture was diluted to the mark with reagent water. The fluorescence of each solution was measured in five separate trials using spectrofluorimetry. The following data was recorded. Fluorescence Emission (Counts) Phenobarbital Std. (mL added) Trial 1 Trial 2 Trial 3 Trial 4 Trial 5 0.00 3.26 3.33 3.25 3.22 3.31 0.50 4.80 4.81 4.89 4.77 4.69 1.00 6.41 6.50 6.48 6.38 6.35 1.50 8.02 8.01 7.89 7.93 8.02 2.00 9.56 9.44 9.49 10.03 9.55 3.00 12.84 12.82 12.88 12.86 12.79 4.00 16.02 16.01 16.07 16.06 16.06 5.00 19.44 19.45 19.39 19.47 19.44 6.00 22.81 22.87 22.91 22.78 22.82 1. Evaluate the calibration data and use statistics to eliminate any outliers and/or leverage points. Plot the final calibration data and determine R2 and the equation of the line of best fit. (4 marks) 2. Report the concentration of phenobarbital in the Luminal tablet in w/w %. (6 marks)
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Cost Benefit Analysis Concepts and Practice
ISBN: 978-0137002696
4th edition
Authors: Anthony Boardman, David Greenberg, Aidan Vining, David Weimer
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