An experimental screening test for HSV-2 was administered to 400 patients who were previously confirmed to have the virus, and to 500 patients who were confirmed not to have it. The screening test came up positive for 384 of those who have HSV-2, and negative for 470 of those who do not have the virus.

a. Estimate the sensitivity and specificity of the screening test.

b. Suppose that 16% of the adult population of the United States are infected with HSV-2. Assuming the sensitivity and specificity calculated in part (a) are the actual values, determine the predictive value positive of the screening test in the adult U.S. population. Interpret your answer.

c. Determine the predictive value negative of the screening test in the adult U.S. population. Interpret your answer.