Question: Arrestin binds to a phosphorylated ligand - receptor complex, blocking the binding and activation of G - proteins, according to the following reaction: + 1

Arrestin binds to a phosphorylated ligand-receptor complex, blocking the binding and activation of G-proteins, according to the following reaction: +1+1 Arrestin binds reversibly with LR with a dissociation constant of =/, in units of molecules per cell. Only free LR can bind to G-proteins. A balance on LR yields =+ To determine the effect of arrestin on G-protein activation, the experiment described above for Problem 2 was repeated in the absence of the drug that inhibits arrestin biniding

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