Question: Assume you do not have the resources to solve structures (X-ray , NMR, electron diffraction, etc) to determine how your ligand binds to the beta
Assume you do not have the resources to solve structures (X-ray , NMR, electron diffraction, etc) to determine how your ligand binds to the beta 1 adrenergic receptor at atomic resolution.
Propose a simple experiment to prove that the putative allosteric ligand you identified does not bind to the orthosteric site? using radiolabeled ligand
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