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F$24-$BIO $12001$

$5.$ Legionella pneumophila and Vibrio cholerae are two pathogens that are spread through the same vehicle.

a$.$ Think about the reservoir for each of these pathogens. Would testing their respective reservoirs for coliforms alert local health authorities about the possibility of contamination with these organisms? In your answer, briefly describe the reservoir for each of these organisms and their mode of infection $(8$ pts $).$

$6$a$.$ In the $1900\text{'}$s Paul Ehrlich postulated that selective toxicity, the ability to inhibit or kill a pathogen without affecting the host, is the most desired characteristic of an antimicrobial drug. How can Selective Toxicity be explained at the molecular level? Use an antifungal drug as an example $(5$ pts$).$

$6$b$.$ List and explain THREE molecular mechanisms that might lead a microbe to become resistant to the antibiotic Penicillin. $(3$ pts$).$

Mech $1$

Mech $2$

Mech $3$

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