Based on these data, at which respiratory complex does itaconate act? Explain your answer.

Match the words in the left column to the appropriate blanks in the sentence on the right.

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reduced

complex III

complex I

complex II

oxidized

complex IV

Itaconate acts at Blank.target $1$ of $9$

Succinate is Blank by Blank $($succinate dehydrogenase$),$ which catalyzes transfer of electrons from succinate to CoQCoQ.target $2$ of $9$target $3$ of $9$

Rotenone is included to block reverse electron flow from reduced CoQH$2$CoQH$2$ back through Blank.target $4$ of $9$

The glutamate and pyruvate are both Blank by Blank.target $5$ of $9$target $6$ of $9$

Ascorbate$/$TMPD is Blank by Blank.target $7$ of $9$target $8$ of $9$

Only the succinate$/$rotenone reaction $($Blank$)$ was inhibited by itaconate.target $9$ of $9$

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Part B

What kind of inhibitor would you predict itaconate to be$?$

irreversiblecompetitivenoncompetitive

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Part C

The endogenous source of itaconate is via decarboxylation of one of the citric acid cycle intermediates. Which is the most likely substrate for this decarboxylation reaction?

isocitratecitratecis$-$aconitatemalateoxalosuccinatefumarate

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