Question: ( c ) Recently, in vivo testing has shown that the substituted 1 , 4 - dihydropyridine F shown below has anticonvulsant activity. It can
c Recently, in vivo testing has shown that the substituted dihydropyridine shown below has anticonvulsant activity. It can be prepared using the Hantzsch synthesis.
i Show the starting materials that would be required to prepare using a Hantzsch synthesis. marks
ii Summarise the three main stages involved in the overall reaction.
marks
iii Draw out a mechanism for ONE of these three stages. Ensure that you also provide a short written description of the mechanism you have drawn.
marks
F
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