Can we work on this problem

A person is heterozygous for a missense mutation in an autosomally located RTK gene that abolishes tyrosine kinase activity. Assuming the mutation only affects kinase function, what level of overall RTK activity would you expect to observe in cells from this person compared to an unaffected relative ? PE Poll Q4 LO 4 signal molecule signal molecule A. 75 % CYTOSOL CYTOSOL B. 50% tyrosine normal - mutant kinase tyrosine tyrosine C. 25 % domain kinase kinase domain domain D. 0% inactive RTKs cross-phosphorylation no kinase by activated kinase domains activation NORMAL RTK ACTIVATION DOMINANT-NEGATIVE INHIBITION BY MUTANT RTK "gare 15-53a Molecular Biology of the Cell 3s 10 Garland Forare 15:525 Melonslar Biology of the Cell S/e (o Garland Science 2105) (Mutual cross phosphorylation required for full kinase activity) Note - each cell can express from 300,000 molecules of RTK's on its cell surface, depending on the RTK and the cell type. D103 Cell Biology ALS 19 @ MacGregor, Suetterlin and Wang - All rights reserved