Can we work on this problem now

PE Poll Q2 Why is it contraindicated (could produce risk) to use Viagra (sildenafil) and nitrates at the same time ? LO 1 2 A. The combination of these drugs can produce an unsafe increase in blood pressure. B. The combination of these drugs could produce an unsafe decrease in blood pressure. C. The combination of these drugs counteract each other's effect. . Viagra inhibits a CGMP D. The combination of these drugs produce an additive effect. phosphodiesterase (PDE5). E. B and D. + Pfizer = ? Nitroglycerin spray used to treat angina. Nitrolingual-Spray Viagra L-arginine Nitroglycerin - nitrite (NO2-) - nitric oxide (NO) Endothelial NO NOS Cell smooth muscle cells basal lamina The concomitant use of sildenafil and nitrates is contraindicated. Smooth NO Muscle lumen of GMP blood vessel All men presenting with acute coronary GC PDE5 syndromes must be asked if they've used Viagra within the preceding 24 GTP TCGMP hours. Relaxation nerve All patients given Viagra must be endothelial cell repeatedly told not to take nitrates