Can we work on this problem

What controls the specificity of an interaction between a SH2-domain containing 'interacting' protein and a specific phospho-tyrosine on a `target' protein ? PE Poll Q3 LO 3 PDGF receptor plasma membrane CYTOSOL PI 3-kinase P Tyr 740 (regulatory subunit) split P Tyr 751 tyrosine kinase GTPase-activating P Tyr 771 domain protein (GAP) phospholipase C-y P Tyr 1009 (PLCy) Tyr 1021 SH2 domains SH3 domain Figure 15-46a Molecular Biology of the Cell Ge [O Garland Science 2015) A. The phosphorylation status of the SH2 domain B. The number of SH3 domains in the interacting protein C. The amino acid sequences surrounding the tyrosine residue that is phosphorylated D. The amino acid sequences surrounding the phosphotyrosine binding site in the SH2 domain E. C and D