can we work on this problem

Which describes how the cell knows when all chromosomes have become stably captured by microtubules at metaphase ? A. Chromosomes that have been captured by microtubules from opposing centrosomes send a signal that increases with each captured chromosome, until a threshold necessary to activate APC/C is reached. B. Non-captured chromosomes bind to securin and prevent it from activating separase. C. Non-captured chromosomes bind to APC/C and prevent it from activating degradation of M- cyclin / CDK. D. Non-captured chromosomes prevent Cdc20 from activating APC/C. E. Non-captured chromosomes inhibit M-cyclin / CDK activity. Prometaphase Metaphase PE Poll Q5 LO D103 Cell Biology ALS 24 Page 6