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3. Heritable Epigenetic Alterations Other forms of heritable modifications to the genome of cancer cells include epigenetic alterations. These do not 4 Methyl Group involve a change in the nucleotide sequence. Epigenetic alterations, such as methylation or acetylation of histones, can lead to increased or decreased gene expression by changing how genetic information can be accessed by the Chromatin transcriptional machinery. Other epigenetic mechanisms Epigenetic Factor include DNA methylation, other histone modifications Histone Histone Tails (e.g., phosphorylation), and microRNA gene silencing. Chromosome Perturbation of epigenetic mechanisms can lead to inactivation of tumour suppressor genes or the The incorporation of epigenetic alterations as DNA activation of oncogenes, which can be passed on from condenses into chromosomes. Click to enlarge. parent to offspring. For your interest, click here to read an article about the mechanisms of epigenetic modifications in cancer