An antihistamine has an n-octanol-water partition coefficient of 1,899 and a pka of 8.0. i. What...
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An antihistamine has an n-octanol-water partition coefficient of 1,899 and a pka of 8.0. i. What is the logP value. Is the antihistamine lipophilic or hydrophilic? Give reasons for your answer. ii. Will the antihistamine be more ionised at pH 2 or pH 7? Calculate the fraction ionised at each of these pH values. Show all calculations. iii. At what pH will the antihistamine be 50% ionised? iv. Calculate the Ka of the antihistamine. v. Explain the difference between partition coefficient and distribution coefficient. An antihistamine has an n-octanol-water partition coefficient of 1,899 and a pka of 8.0. i. What is the logP value. Is the antihistamine lipophilic or hydrophilic? Give reasons for your answer. ii. Will the antihistamine be more ionised at pH 2 or pH 7? Calculate the fraction ionised at each of these pH values. Show all calculations. iii. At what pH will the antihistamine be 50% ionised? iv. Calculate the Ka of the antihistamine. v. Explain the difference between partition coefficient and distribution coefficient.
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i The noctanolwater partition coefficient or K ow is a partition coefficient for noctanol and water ... View the full answer
Related Book For
An Introduction to Statistical Methods and Data Analysis
ISBN: 978-1305269477
7th edition
Authors: R. Lyman Ott, Micheal T. Longnecker
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