Chymotrypsin, trypsin, and elastase are digestive enzymes called serine proteases. The serine proteases differ in substrate...
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Chymotrypsin, trypsin, and elastase are digestive enzymes called serine proteases. The serine proteases differ in substrate specificity: Chymotrypsin cleaves peptide bonds after aromatic or bulky hydrophobic side chains; trypsin requires basic amino acid residues; and elastase cleaves bonds following small uncharged side chains. A chart of amino acids can be found here. The specificity pockets (substrate-binding sites) of each of the serine proteases are drawn below. (a) Determine which specificity pocket is a part of each enzyme. Move each specificity pocket, below, to the proper bin. (b) Which of the following amino acids have side chains that fit into the specificity pocket of trypsin? Select all the amino acids that fit. You will need to check more than one amino acid. Note: If you answer part (a) incorrectly, a single red X will appear indicating that one or more of the answers are sorted incorrectly. X Chymotrypsin Trypsin Elastase 7 phenylalanine glycine lysine arginine aspartate alanine Incorrect. You have incorrectly placed the trypsin pocket. Trypsin cleaves peptide bonds following basic, positively charged side chains. Consider the charges on amino acid side chains inside the pocket. Chymotrypsin, trypsin, and elastase are digestive enzymes called serine proteases. The serine proteases differ in substrate specificity: Chymotrypsin cleaves peptide bonds after aromatic or bulky hydrophobic side chains; trypsin requires basic amino acid residues; and elastase cleaves bonds following small uncharged side chains. A chart of amino acids can be found here. The specificity pockets (substrate-binding sites) of each of the serine proteases are drawn below. (a) Determine which specificity pocket is a part of each enzyme. Move each specificity pocket, below, to the proper bin. (b) Which of the following amino acids have side chains that fit into the specificity pocket of trypsin? Select all the amino acids that fit. You will need to check more than one amino acid. Note: If you answer part (a) incorrectly, a single red X will appear indicating that one or more of the answers are sorted incorrectly. X Chymotrypsin Trypsin Elastase 7 phenylalanine glycine lysine arginine aspartate alanine Incorrect. You have incorrectly placed the trypsin pocket. Trypsin cleaves peptide bonds following basic, positively charged side chains. Consider the charges on amino acid side chains inside the pocket.
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Related Book For
Fundamentals of biochemistry Life at the Molecular Level
ISBN: 978-0470547847
4th edition
Authors: Donald Voet, Judith G. Voet, Charlotte W. Pratt
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