Consider the metabolic network shown below. Assume that all reactions follow mass action kinetics. Also assume...
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Consider the metabolic network shown below. Assume that all reactions follow mass action kinetics. Also assume the influx rate V71 is 20 mM/min, the efflux rate V3.0 is 30 mM/min, and all other fluxes have a value of 10 mm/min. a. Write the 8 reactions for this network. Ensure the number of carbon atoms is mass- balanced by using the table below. b. Compute the rate constants of all processes, with the following steady state concentrations (in units of mM): X, = 10, X = 6, X3= 12, X4 = 8, Xs = 8, X6 = 4, X7 = 20. c. Assume all metabolite concentrations are initially zero, with the exception of X7, which is 20 mm. Simulate the model using MATLAB, and plot all metabolite concentrations as a function of time. Confirm that the steady state concentrations given in c) are attained. GEP V FEP () V3 GAP V Vas 00 STP gl X(X) Va RISP: XS: RUSP () VL V GAP () E4P(X) V VAS Compound pool No. of carbon atoms X X X3 X Xs X6 X 7346655 Consider the metabolic network shown below. Assume that all reactions follow mass action kinetics. Also assume the influx rate V71 is 20 mM/min, the efflux rate V3.0 is 30 mM/min, and all other fluxes have a value of 10 mm/min. a. Write the 8 reactions for this network. Ensure the number of carbon atoms is mass- balanced by using the table below. b. Compute the rate constants of all processes, with the following steady state concentrations (in units of mM): X, = 10, X = 6, X3= 12, X4 = 8, Xs = 8, X6 = 4, X7 = 20. c. Assume all metabolite concentrations are initially zero, with the exception of X7, which is 20 mm. Simulate the model using MATLAB, and plot all metabolite concentrations as a function of time. Confirm that the steady state concentrations given in c) are attained. GEP V FEP () V3 GAP V Vas 00 STP gl X(X) Va RISP: XS: RUSP () VL V GAP () E4P(X) V VAS Compound pool No. of carbon atoms X X X3 X Xs X6 X 7346655
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a The 8 reactions for the metabolic network can be written as follows Reaction R1 X1 X2 X3 Reaction ... View the full answer
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