Question: Consider the receptor-ligand binding interaction covered in the class notes: Kd=[RL][R][L];Ka=[R][L][RL] A) Assuming that [R], [L], and [R.L] are all given in molar, what are

 Consider the receptor-ligand binding interaction covered in the class notes: Kd=[RL][R][L];Ka=[R][L][RL]
A) Assuming that [R], [L], and [R.L] are all given in molar,

Consider the receptor-ligand binding interaction covered in the class notes: Kd=[RL][R][L];Ka=[R][L][RL] A) Assuming that [R], [L], and [R.L] are all given in molar, what are the units for Kd? What are the A) Assuming that [R], [L], and [R.L] are all given in molar, what are the units for Kd? What are the units for Ka ? B) When [L]=Kd (i.e. the concentration of the ligand is equal to the dissociation constant), what is the value of [R]/[R.L] ? What does that tell you about the concentrations of [R] and [R.L] ? C) In the "real world", people are interested in the Kd for a ligand-receptor interaction, not really the Ka. Why is that? Another way to think about this, is what does the Kd "tell us" about whall concentration of ligand we should use if we want to ensure good binding to the recepton? (HINT: you can think about this in the following way: what would happen if [L]Kd ? or if [L]>>Kd ?) Edit View Insert Format Tools Table 12 pt Paragraph BABIAT2

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